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Cancer Research & Clinical Trials

At Mitchell Memorial Cancer Center, we’re continually looking for the innovations of tomorrow. Who will discover the next breakthrough in cancer treatment – or even the next cure?

The answer lies in research – and it’s a key part of our vision at MMCC.

Owensboro Cancer Research Program

Established as a joint venture between Owensboro Health and the University of Louisville’s James Graham Brown Cancer Center, the Owensboro Cancer Research Program has a deceptively simple goal: unlocking the potential of plant-based therapies.

In medical jargon, we focus on using plant-based expression systems to produce protein-based therapeutics and diagnostic reagents for clinical trials and commercial production. In simple terms, that means we’re finding ways to extract proteins and other chemicals from plants so we can turn them into accessible, affordable cancer treatments.

OCRP In The News

One example of our research success appeared in a prestigious academic journal in March 2009.

The Proceedings of the National Academy of Sciencesfeatured research by Kenneth Palmer, Ph.D., touting a protein called

griffithsin, which binds sugar molecules on the surface of HIV, preventing the virus from infecting cells of the immune system.

HIV research is one of OCRP’s strategic initiatives because the virus increases an individual’s risk for cancer.

One of the current major research studies at OCRP is the development of a second-generation cervical cancer vaccine from tobacco plants. Vaccines like this will be both accessible and affordable to millions of women worldwide, from India to sub-Saharan Africa and across rural areas of the United States.

Other key projects underway at OCRP include:

  • Developing a plant-based vaccine to prevent HIV.
  • Understanding how changes in the calcium-signaling pathway of stem cells impacts the development and continued growth of lung cancer cells.
  • Determining whether the interaction of the heavy metal cadmium with tobacco-derived carcinogens contributes to the development of lung cancer in smokers.
Other recent accomplishments in cancer research include:

Current faculty

Since our launch in 2007, OCRP has grown to 24 researchers, including eight Ph.D. scientists. Our current faculty members and their research interests are:

Keith Davis, Ph.D.

Professor and Executive Director Plant biotechnology and the improvement of plant-based protein expression and vaccine production, the development of the soy peptide lunasin as an anti-cancer agent and the role of cadmium in the initiation of lung cancer.

Kenneth Palmer, Ph.D.

Associate Professor Development of a new plant-expressed HPV vaccine for cervical cancer, and development of a novel antiviral protein with broad activity against HIV and potential bioterrorism agents such as Ebola virus.

 

Uma Sankar, Ph.D.

Associate Professor Regulation of hematopoitic stem cell development and blood-based cancers and identification of genes important for cancer stem cell survival.

 


Nobuyuki Matoba, Ph.D.

Associate Professor Development of plant-based HIV and cancer vaccines.

To learn more about the Owensboro Cancer Research Program, call (270) 688-3694 or email executive director Keith Davis, Ph.D.

Clinical Trials

Through MMCC’s active participation in important clinical trial networks, cancer patients in the Owensboro region can become involved in important research that could help change the way cancer is treated in the future.

Participants in clinical trials receive world-class treatment – often with little or no financial cost. The trials are developed and managed through prestigious organizations across the country, including public and private universities, research foundations and pharmaceutical companies.  Learn more about clinical trials offered at Owensboro Health.

MMCC’s network affiliations include Vanderbilt-Ingram Cancer Center Affiliation Network, Kentucky Clinical Trials Network and Eastern Cooperative Oncology Group.

Interested in participating in a clinical trial? Email Judy Strobel or call (270) 691-8094.

Internships

Ten weeks at a world-class, state-of-the-art cancer research facility. Learn hands-on laboratory techniques from nationally renowned scientists. Contribute to ongoing research projects in areas such as cancer biology and plant-made pharmaceuticals.

How much would you learn? How much would you grow?

Ready for the Challenge?

If that sounds like a great summer to you, the Owensboro Cancer Research Program could be just the opportunity for you. OCRP is partnering with the Owensboro Health Foundation for Health’s Medicus Society to offer full-time research internships for pre-medical and pre-dental undergraduate students.

The program offers pre-professional students a rigorous research experience under the guidance of an OCRP faculty mentor. We think you'll love Owensboro - and a summer at OCRP will be an experience that could shape your future.

How it Works

  • OCRP is housed in the Mitchell Memorial Cancer Center (MCCC), located on the Owensboro Health main campus.
  • Each student participant will receive a stipend of $3,500 over the ten-week period.
  • Free communal housing is available with other interns and medical students participating in OCRP summer research programs.

Eligibility

All pre-medical and pre-dental students are eligible to apply if they:

  • Are completing their junior year of college prior to the start of the program; AND/OR
  • Have completed introductory chemistry and biology courses.

How to apply

Download an application

In addition to the application form, applicants should submit:

  • Transcripts
  • One page description of career goals
  • Two letters of reference from the applicant's home institution

Submitting Application

Electronic submission (preferred): keith.davis@louisville.edu

By mail:

Keith R. Davis, Ph.D.
Medicus Society Summer Research Intern Program
Suite 201 , Mitchell Memorial Cancer Center 
1020 Breckenridge Street
Owensboro, KY 42303

Additional Info 

For more information about our cancer research programs and clinical trials, call MMCC at (800) 947-7102 or (270) 688-3600.