Leslie-Obrest-2018.jpg M. Leslie  Oberst, M. Leslie  Oberst,

M. Leslie Oberst, MD

Specializing in Cardiology
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Accepting new patients

Affiliation: Owensboro Health

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Physician Profile

A patient's message

Read a message sent to Dr. Oberst on National Doctors' Day.

"Dr. Leslie Oberst, although your services are relatively new to me, I want to thank you for your taking the time and your thoroughness in getting to know me and my health background. I appreciate your friendly approach and interaction. Welcome again to Owensboro and have a Happy Doctors' Day." - Nancy

Education & Training


  • University of Louisville School of Medicine, Doctor of Medicine


  • Rush-Presbyterian / St. Luke's Medical Center, Internal Medicine


  • Baylor College of Medicine, Cardiology


  • Rush-Presbyterian / St. Luke's Medical Center, Internal Medicine

Board Certified

  • American Board of Internal Medicine, Cardiovascular Disease


  • Lim OS, Oberst L, McCluggage M, Youker K, Lacy J, DeMayo F, Entman ML, Roberts R, Michael LH, Marian AJ. Decreased left ventricular ejection fraction in transgenic mice expressing mutant cardiac troponin T-Q(92), responsible for human hypertrophic cardiomyopathy. J Mol Cell Cardiol. 2000;32(3):365-74.
  • Oberst L, Zhao G, Park JT, Brugada R, Michael LH, Entman ML, Roberts R, Marian AJ. Dominant-negative effect of a mutant cardiac troponin Ton cardiac structure and function in transgenic mice. J Clin Invest. 1998 Oct 15;102(8):1498-505.
  • Marian AJ, Oberst L, Nyhm H, Brugada R, Roberts R. Dominant negative effects of a mutant cardiac troponin T, known to cause hypertrophic cardiomyopathy in man, in myofibrillar structure in transgenic mice. Journal of Investigative Medicine; 1998: 46:235A 
  • Oberst L, Zhao G, Park J, Brugada R, Marian Roberts R. Structure-function studies in transgenic mice expressing a mutant human cardiac Troponin T responsible for hypertrophic cardiomyopathy. Circulation 1998: 1-235-236. 
  • Zhao J, Oberst L, Zhao G, Park J, Youker K, Entman M, Michael L, Lacy J, Roberts R, Marian A. Expression of a human hypertrophic cardiomyopathy mutation in transgenic mice impairs left ventricular systolic function, detected by TA radionuclide angiography, which precedes histological changes. Journal of the American College of Cardiology 199;33:3A