imgs-doctors-FrancisDuFrayne375x500.jpg Francis  DuFrayne, Francis  DuFrayne,

Francis DuFrayne, MD

Specializing in Gastroenterology

Referral required

Affiliation: Owensboro Health

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Owensboro Health is honored to have Francis Dufrayne, MD, as its Executive Vice President and health system Chief Medical Officer.

Dr. DuFrayne is board certified in both Internal Medicine and Gastroenterology. He came to Owensboro Health in 2012 from Philadelphia.

In addition to his administrative role, Dr. DuFrayne cares for patients with Owensboro Health Gastroenterology & Hepatology.

Dr. DuFrayne completed medical school at Temple University School of Medicine and an internal medicine residency at Pennsylvania Hospital. He also completed a fellowship in gastroenterology at Hospital of the University of Pennsylvania.

Education & Training


  • Temple University School of Medicine


  • Pennsylvania Hospital, Internal Medicine


  • Hospital of the University of Pennsylvania, Gastroenterology

Board Certified

  • American Board of Internal Medicine
  • American Board of Internal Medicine, Gastroenterology¬†

Additional Information

A patient's message

Read the messages sent to Dr. DuFrayne on National Doctors' Day.

"Thank you for saving my life. You are the best." - Stan

"Thank you, sir, for the care and knowledge you have that has helped me still in remission for the longest time in my life." - Marjorie

"Dr. Dufrayne, thank you for always being so kind and caring. So glad to have you as my doctor." - Stephanie

"Thank you Dr. DuFrayne, (and all of the staff at the outpatient surgery department) for making my recent outpatient procedure such an easy and painless procedure. We're so fortunate to have a professional with your skills at this facility!" - Anthony


COVID-19 Vaccines and Type 1 Diabetes

Owensboro Health Chief Medical Officer Dr. Francis DuFrayne and Endocrinologist Dr. Betty Villafuerte joined the JDRF Indiana & Kentucky Community Board President Dr. Malone to discuss Type 1 Diabetes and COVID-19. Watch as they discuss what you should know about the vaccine and answer questions relevant to diabetics.